The source of the memory impairment in Parkinson's disease: acquisition versus retrieval.
Identifieur interne : 000382 ( Main/Exploration ); précédent : 000381; suivant : 000383The source of the memory impairment in Parkinson's disease: acquisition versus retrieval.
Auteurs : Nancy D. Chiaravalloti [États-Unis] ; Naroa Ibarretxe-Bilbao ; John Deluca ; Olga Rusu ; Javier Pena ; Inés García-Gorostiaga ; Natalia OjedaSource :
- Movement disorders : official journal of the Movement Disorder Society [ 1531-8257 ] ; 2014.
English descriptors
- KwdEn :
- Aged, Case-Control Studies, Female, Humans, Male, Memory Disorders (etiology), Memory, Long-Term (physiology), Mental Recall (physiology), Mental Status Schedule, Middle Aged, Neuropsychological Tests, Parkinson Disease (complications), Severity of Illness Index, Statistics as Topic, Statistics, Nonparametric.
- MESH :
- complications : Parkinson Disease.
- etiology : Memory Disorders.
- physiology : Memory, Long-Term, Mental Recall.
- Aged, Case-Control Studies, Female, Humans, Male, Mental Status Schedule, Middle Aged, Neuropsychological Tests, Severity of Illness Index, Statistics as Topic, Statistics, Nonparametric.
Abstract
Memory deficits are common in persons with Parkinson's disease (PD) even without the presence of a frank dementia. These memory deficits have traditionally been attributed to inability of patients to retrieve information from long-term memory, referred to as the "retrieval failure hypothesis." However, some studies additionally document problems in recognition memory, noted to be inconsistent with the retrieval failure hypothesis. Given the neuroanatomical abnormalities observed in the hippocampus of PD patients and the role of the hippocampus in learning new information, the current study was designed to specifically examine learning abilities in a nondemented PD sample through the application of a learning paradigm, the Open Trial Selective Reminding Test. We examined 27 patients with PD without dementia and 27 age-, gender-, and education-matched healthy controls (HCs) with a neuropsychological test battery designed to assess new learning and memory. Results indicated a significant difference between the groups in terms of their ability to learn a list of 10 semantically related words. However, once the groups were equated on learning abilities, no significant difference was noted between the PD and HC participants in recall or recognition of the newly learned material. The memory deficit observed in nondemented PD patients is thus largely the result of a deficit in learning new information. This finding should be used to guide treatment for memory deficits in persons with PD, and future research should seek to identify novel means of improving new learning in this population.
DOI: 10.1002/mds.25842
PubMed: 24615718
Affiliations:
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Le document en format XML
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Chiaravalloti</name><affiliation wicri:level="2"><nlm:affiliation>Kessler Foundation, West Orange, New Jersey, USA; Department of Physical Medicine and Rehabilitation, Rutgers New Jersey Medical School, Newark, New Jersey, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Kessler Foundation, West Orange, New Jersey, USA; Department of Physical Medicine and Rehabilitation, Rutgers New Jersey Medical School, Newark, New Jersey</wicri:regionArea><placeName><region type="state">New Jersey</region></placeName></affiliation></author><author><name sortKey="Ibarretxe Bilbao, Naroa" sort="Ibarretxe Bilbao, Naroa" uniqKey="Ibarretxe Bilbao N" first="Naroa" last="Ibarretxe-Bilbao">Naroa Ibarretxe-Bilbao</name></author><author><name sortKey="Deluca, John" sort="Deluca, John" uniqKey="Deluca J" first="John" last="Deluca">John Deluca</name></author><author><name sortKey="Rusu, Olga" sort="Rusu, Olga" uniqKey="Rusu O" first="Olga" last="Rusu">Olga Rusu</name></author><author><name sortKey="Pena, Javier" sort="Pena, Javier" uniqKey="Pena J" first="Javier" last="Pena">Javier Pena</name></author><author><name sortKey="Garcia Gorostiaga, Ines" sort="Garcia Gorostiaga, Ines" uniqKey="Garcia Gorostiaga I" first="Inés" last="García-Gorostiaga">Inés García-Gorostiaga</name></author><author><name sortKey="Ojeda, Natalia" sort="Ojeda, Natalia" uniqKey="Ojeda N" first="Natalia" last="Ojeda">Natalia Ojeda</name></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2014">2014</date><idno type="RBID">pubmed:24615718</idno><idno type="pmid">24615718</idno><idno type="doi">10.1002/mds.25842</idno><idno type="wicri:Area/PubMed/Corpus">000557</idno><idno type="wicri:Area/PubMed/Curation">000557</idno><idno type="wicri:Area/PubMed/Checkpoint">000384</idno><idno type="wicri:Area/Ncbi/Merge">003F41</idno><idno type="wicri:Area/Ncbi/Curation">003F41</idno><idno type="wicri:Area/Ncbi/Checkpoint">003F41</idno><idno type="wicri:Area/Main/Merge">000382</idno><idno type="wicri:Area/Main/Curation">000382</idno><idno type="wicri:Area/Main/Exploration">000382</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">The source of the memory impairment in Parkinson's disease: acquisition versus retrieval.</title><author><name sortKey="Chiaravalloti, Nancy D" sort="Chiaravalloti, Nancy D" uniqKey="Chiaravalloti N" first="Nancy D" last="Chiaravalloti">Nancy D. Chiaravalloti</name><affiliation wicri:level="2"><nlm:affiliation>Kessler Foundation, West Orange, New Jersey, USA; Department of Physical Medicine and Rehabilitation, Rutgers New Jersey Medical School, Newark, New Jersey, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Kessler Foundation, West Orange, New Jersey, USA; Department of Physical Medicine and Rehabilitation, Rutgers New Jersey Medical School, Newark, New Jersey</wicri:regionArea><placeName><region type="state">New Jersey</region></placeName></affiliation></author><author><name sortKey="Ibarretxe Bilbao, Naroa" sort="Ibarretxe Bilbao, Naroa" uniqKey="Ibarretxe Bilbao N" first="Naroa" last="Ibarretxe-Bilbao">Naroa Ibarretxe-Bilbao</name></author><author><name sortKey="Deluca, John" sort="Deluca, John" uniqKey="Deluca J" first="John" last="Deluca">John Deluca</name></author><author><name sortKey="Rusu, Olga" sort="Rusu, Olga" uniqKey="Rusu O" first="Olga" last="Rusu">Olga Rusu</name></author><author><name sortKey="Pena, Javier" sort="Pena, Javier" uniqKey="Pena J" first="Javier" last="Pena">Javier Pena</name></author><author><name sortKey="Garcia Gorostiaga, Ines" sort="Garcia Gorostiaga, Ines" uniqKey="Garcia Gorostiaga I" first="Inés" last="García-Gorostiaga">Inés García-Gorostiaga</name></author><author><name sortKey="Ojeda, Natalia" sort="Ojeda, Natalia" uniqKey="Ojeda N" first="Natalia" last="Ojeda">Natalia Ojeda</name></author></analytic><series><title level="j">Movement disorders : official journal of the Movement Disorder Society</title><idno type="eISSN">1531-8257</idno><imprint><date when="2014" type="published">2014</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Aged</term><term>Case-Control Studies</term><term>Female</term><term>Humans</term><term>Male</term><term>Memory Disorders (etiology)</term><term>Memory, Long-Term (physiology)</term><term>Mental Recall (physiology)</term><term>Mental Status Schedule</term><term>Middle Aged</term><term>Neuropsychological Tests</term><term>Parkinson Disease (complications)</term><term>Severity of Illness Index</term><term>Statistics as Topic</term><term>Statistics, Nonparametric</term></keywords><keywords scheme="MESH" qualifier="complications" xml:lang="en"><term>Parkinson Disease</term></keywords><keywords scheme="MESH" qualifier="etiology" xml:lang="en"><term>Memory Disorders</term></keywords><keywords scheme="MESH" qualifier="physiology" xml:lang="en"><term>Memory, Long-Term</term><term>Mental Recall</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Aged</term><term>Case-Control Studies</term><term>Female</term><term>Humans</term><term>Male</term><term>Mental Status Schedule</term><term>Middle Aged</term><term>Neuropsychological Tests</term><term>Severity of Illness Index</term><term>Statistics as Topic</term><term>Statistics, Nonparametric</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Memory deficits are common in persons with Parkinson's disease (PD) even without the presence of a frank dementia. These memory deficits have traditionally been attributed to inability of patients to retrieve information from long-term memory, referred to as the "retrieval failure hypothesis." However, some studies additionally document problems in recognition memory, noted to be inconsistent with the retrieval failure hypothesis. Given the neuroanatomical abnormalities observed in the hippocampus of PD patients and the role of the hippocampus in learning new information, the current study was designed to specifically examine learning abilities in a nondemented PD sample through the application of a learning paradigm, the Open Trial Selective Reminding Test. We examined 27 patients with PD without dementia and 27 age-, gender-, and education-matched healthy controls (HCs) with a neuropsychological test battery designed to assess new learning and memory. Results indicated a significant difference between the groups in terms of their ability to learn a list of 10 semantically related words. However, once the groups were equated on learning abilities, no significant difference was noted between the PD and HC participants in recall or recognition of the newly learned material. The memory deficit observed in nondemented PD patients is thus largely the result of a deficit in learning new information. This finding should be used to guide treatment for memory deficits in persons with PD, and future research should seek to identify novel means of improving new learning in this population.</div></front></TEI><affiliations><list><country><li>États-Unis</li></country><region><li>New Jersey</li></region></list><tree><noCountry><name sortKey="Deluca, John" sort="Deluca, John" uniqKey="Deluca J" first="John" last="Deluca">John Deluca</name><name sortKey="Garcia Gorostiaga, Ines" sort="Garcia Gorostiaga, Ines" uniqKey="Garcia Gorostiaga I" first="Inés" last="García-Gorostiaga">Inés García-Gorostiaga</name><name sortKey="Ibarretxe Bilbao, Naroa" sort="Ibarretxe Bilbao, Naroa" uniqKey="Ibarretxe Bilbao N" first="Naroa" last="Ibarretxe-Bilbao">Naroa Ibarretxe-Bilbao</name><name sortKey="Ojeda, Natalia" sort="Ojeda, Natalia" uniqKey="Ojeda N" first="Natalia" last="Ojeda">Natalia Ojeda</name><name sortKey="Pena, Javier" sort="Pena, Javier" uniqKey="Pena J" first="Javier" last="Pena">Javier Pena</name><name sortKey="Rusu, Olga" sort="Rusu, Olga" uniqKey="Rusu O" first="Olga" last="Rusu">Olga Rusu</name></noCountry><country name="États-Unis"><region name="New Jersey"><name sortKey="Chiaravalloti, Nancy D" sort="Chiaravalloti, Nancy D" uniqKey="Chiaravalloti N" first="Nancy D" last="Chiaravalloti">Nancy D. 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